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Acute Renal Failure Research

Acute Renal Failure: Research

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1. Biomarkers to identify acute renal failure in serious patients

Acute renal failure has severe consequences, with twenty five to eight percent of patients running risks of in-hospital deaths. However, in a path breaking new discovery, researchers have a found a way to diagnose acute renal failure using urine tests. The findings will enable emergency departments at hospitals to identify high risk patients upon admission. In determining kidney functions, physicians generally measure the creatinine levels. However, the tricky part here is creatinine levels have often been found remaining normal for several hours following kidney damage. To make accurate assessments, the measurements should be taken over a period of one to three days. This considerably limits their usefulness in emergency situations. The international study, conducted by researchers from Universities and clinics like the Columbia University and Helios Clinics, Germany based its findings on the results of a single measure of 5 urinary biomarkers collected from 1,635 patients admitted to the Emergency ward.

Via: http://www.sciencedaily.com/releases/2012/01/120109212013.htm

2. Kidney disease linked to acute renal failure in diabetic patients

The risk for chronic kidney disease grows with multiple acute renal failure episodes during the patient’s stay at a hospital, especially if he or she has diabetes, says a latest research. Diabetes mellitus, it has been observed, is the largest contributor to the rising prevalence of kidney diseases. Diabetic patients may encounter multiple hospitalizations from a plethora of problems in the long run, the study further reports. The research, conducted by the University of Cincinnati, aimed primarily at studying the effects of multiple acute renal failure instances on the risks of severe kidney diseases in diabetic patients. Another target for the research team was to establish the link’s independence from commonly found risk factors of diabetic renal failure like high blood pressure.

Via: http://www.thirdage.com/news/chronic-kidney-disease-linked-to-acute-kidney-injuries-in-diabetic-patients_11-02-2011

3. A brand new drug target for patients facing risks of acute renal failure

In a latest study, researchers have identified the regulator protein which plays an important role in kidney fibrosis- a condition which leads to acute renal failure. The invention is expected to provide a fresh therapeutic target for patients of kidney failure. In the study, the research team from Mount Sinai School of Medicine analyzed 3 groups of mice. The first group had their genomes incorporated with HIV viral proteins. The second group of mice was injected with folic acid. In the third model, researchers blocked kidney filtration in one kidney. All the factors described above contribute to kidney fibrosis. The team then collected genetic material of the mice and got them compared to genetic materials in those not affected by kidney fibrosis. HIPK2, a protein regulator was found to be highly active in mice having kidney fibrosis.

Via: http://www.sciencedaily.com/releases/2012/03/120312003228.htm

4. Acute renal failure puts elderly patients at increased risk for developing kidney disease

Acute renal failure, which is often triggered by illness, surgery and trauma, puts elderly individuals at risk for developing the most dangerous form of CKD or Chronic Kidney Disease. The findings suggest that in-depth medical follow up is essential for maintaining health conditions in patients with a history of kidney damage. Kidney disease is a pressing problem among millions and millions of people around the world. A plethora of factors like hypertension, diabetes, or ageing add vent to the patient’s risk of developing the condition. Acute renal failure may also trigger kidney disease, researchers suspect. However, the link is yet to be verified. The research, conducted by a team of doctors at the Minneapolis based United States Renal Data System, was focused at examining the samplings of several medical beneficiaries from the year 2000. Data from around 234,000 patients, aged 67 or older, who had been admitted to the hospital at various stages were analyzed and examined.

Via: http://www.sciencedaily.com/releases/2008/11/081119171320.htm

5. Kidneys of deceased donors with ARF likely to expand the donor pool, says research

Kidney of donors who died of acute kidney injury, once deemed futile for transplant, now appear to work just as perfectly as kidneys of donors with no previous history of kidney problems, says a latest research. The study, conducted by researchers at the Wake Forest University Baptist Medical Center, indicates the possibility of getting the donor kidney pool expanded securely. According to the research team, there is a serious crisis of donor organs. This is the prime reason why the medical community is making constant efforts to expand the donor pool. While kidneys of donors with acute kidney injury were considered futile sometime back, the recent findings show they can work perfectly well.

Via: http://www.sciencedaily.com/releases/2009/10/091001101328.htm