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Top 5 research topics for Hepatitis A

The Hepatitis A virus

Hepatitis A has been the topic of many ongoing researches being conducted across the world over the past few years. Several scientists in the US and Europe are continuing their research on the virus as you read this article today. Broadly, researchers’ focus has been on this virus’ pathogenesis and the basic line of defense of human body against the virus. Their aim is to determine a possible and effective treatment for it very soon. Hepatitis A has been highly prevalent in US and Europe, however, funding of research in this field has not been as effective as it needs to be. FDA has recently approved funds and provided impetus to these researches through testing, etc., because the scientists are expected to be very close to inventing an effective treatment. Some of the recent studies on Hepatitis A have shown that the treatments that can be useful for majority of cases of this virus are possible. This also includes few cases where patients are in crucial stages. Some better considered research topics for Hepatitis A are described below.

1. Control of Hepatitis A at cellular level

Hepatitis A is hardly known by the cells that are infected and this is the reason that HAV ignores harming its host. Some recent scientific studies have shown that control of HAV infection at cellular level is somewhere easier as compare to any other level. This is something that attracts the attention of scientists towards this research topic. Some scientists proved that cytokines like IL-6 are something that can easily control the Hepatitis A at transcription level. Moreover, it assists in avoiding apoptosis which is the leading reason for majority of deaths occurred in Hepatitis A. Also FDA has approved it recently.

2. Risk factor, causes and incidence

Scientific studies have shown that in majority of cases HAV is quite common in blood as well as stool of a patient of this disease. It starts affecting a person around 30 days before symptoms occur. Majority of scientists have shown that a person is affected in case he/she comes in contact with the blood of a person who is already affected. On the other side, few scientific studies show that it is not always necessary. Thus it is a research topic to consider. In US and Europe, around 4000 cases of HAV reported every year. Some scientists have shown that travel to South or especially Central America is one of the leading risk factors of HAV, while some did not believe it. Other risk factors include staying in a nursing home, use of IV drug and working in sewage department.

3. Therapies that are effective

A latest scientific research on Hepatitis A has shown that for avoiding it what one has to consider is better sanitation, vaccination as well as hygiene. People above 20 years of age can consider vaccine. According to scientists’ latest research, vaccine is something that is effective in more than 90 percent of cases. FDA has tested it and approved it as well. It is still under research that whether it can be useful in avoiding future infection. This actually attracts attention of scientists towards this research topic. Because Hepatitis A is not chronic, thus in majority of countries of Europe and in US, vaccine is given through injection. After first dosage, second is given after a time period of around 6 to 11 months. Follow the link http://emedicine.medscape.com/article/177484-treatment

4. HAV-based vectors

Some scientists in US maintain vectors that are based on HAV for a genre transfer. This research topic is considered by scientists because it has not yet proved that whether these vectors are to be promised or not. Some studies on them show that they are non-cytopathic and they infect hepatocytes. Some other studies in 2003 proved that they avoid co-formation of wild Hepatitis A. There is another thing that attracts the attention of scientists towards this research topic and that is the successful use of these vectors in chimpanzees in the year 2005 in America. This proved that they do not have any side effect and can be used easily. It is a very useful tool for experimental purpose. It has been said that FDA is going to approve it soon. Follow the link http://www.sciencedirect.com/science/article/pii/0168170288900226

5. Age for this virus

Majority of scientific studies has shown that this virus, most of the time, occurs after the age of 20. In England, large number of children is infected through this disease. The cause of this virus in majority of them is not known. Also some scientific researches have shown that causes of HAV in majority of cases in people having age more than 20 are known easily. On the other side, these causes are difficult to find in children. This actually led the scientists to focus on this research topic. Also FDA has approved it for considering few years ago for this reason only.

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