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Can sickle cell crisis cause loss of oxygen to brain?

My brother was admitted to the hospital complaining of weakness. After 2 days, he was finally diagnosed with sickle cell crisis, by then he was not responding. The doctors could not understand why he was comatose. He was transferred to another hospital where he was given a blood exchange. They didn’t know why they couldn’t get him to wake up and concluded that somewhere he had lost oxygen supply to his brain. Could all this be related to the sickle cell crisis, can sickle cell crisis cause loss of oxygen to the brain? Help please!

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