Polycystic ovary syndrome: Research
1. Genetics of polycystic ovary syndrome
Researchers are trying to find out whether the presence of specific genes increase a woman’s chances of getting PCOS. Besides performing genetic and hormonal analysis of blood samples obtained from women of childbearing age with fewer menstrual cycles per year, scientists are also studying the genetic makeup of the close family members. Even the close male relatives of PCOS subjects will undergo laboratory and physical examinations in a similar manner. Identification of specific genes will help to address the therapeutic problems. Moreover, it will help early diagnosis of the ailment. It may also protect the future generations from the hormonal disorder.
2. Relative roles of different treatments in infertile PCOS women
PCOS causes infertility. Inducing ovulation in PCOS patients is the primary challenge of PCOS researches. Currently, clomiphene citrate is widely recommended for inducing ovulation in PCOS patients. However, clomiphene citrate may increase the risk of birth defects. This has led researchers to search for safer and effective alternatives to this common PCOS drug and investigate the effect of improved insulin resistance and hyperandrogenism in increasing the pregnancy outcome in PCOS subjects.
Comparing the effectiveness of insulin resistance and hyperandrogenism treatments in improving fertility in obese PCOS subjects is currently one of the most important areas of PCOS research. The infertile obese PCOS women participating in the study will be divided into three groups. One group of PCOS women will be prescribed meal replacements, medications and lifestyle changes to improve insulin resistance. The second group will be treated for hyperandrogenism with oral contraceptive pills and other drugs. The third group will undergo treatment for both insulin resistance and hyperandrogenism. In the second phase of the study, all the subjects will undergo fertility treatment for improving the chances of ovulation. The findings of the study will help researchers identify the appropriate treatment option for treating fertility in obese PCOS patients.
via: Penn State University
3. Role of vitamin D in treating PCOS
In the recent years, studies have exposed an association between serum vitamin D level and the reproductive health of women. Researches suggest that vitamin D regulates the expression of multiple genes involved in the female reproduction process. Clinical trials are underway to understand the effects of this important vitamin on the quality of life of women with PCOS.
via: National Institutes of Health